The application of computational and analytical methods to biological problems is a rapidly evolving scientific discipline. This book is designed to help any biologist develop a structured approach to data, as well as provide the tools they'll need to analyze it.
Includes graphic elements such as sidebars, reader-alert icons, and boxed highlights that stress selected points from the text, illuminate keys to learning, and give students quick pointers to the essentials. Designed for underprepared students and readers, it aims to deliver help from teachers who are authorities in their fields.
An outline of genetics that provides a review of anatomy and physiology with explanations, accompanied by many exercises. It includes comprehensive review of the chromosome theory of heredity, linkage, gene interactions, maternal inheritance, molecular knowledge, transmission genetics, and the biochemical basis of heredity.
Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is the prime model for genetic and developmental studies, as well as research in genomics. Part of the "Reliable Lab Solutions" series dealing with zebrafish, this title brings together a collection of time-tested methods.
This book brings together the author's research in the study of RNA structures, presenting new combinatorics and combinatorial structures which enhance both mathematics and biology. The author produces pseudo knotted structures, providing an alternative approach.
Uses pragmatic examples and a case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. This title is suitable for students and professionals involved with gene or protein expression data in a variety of settings.
The mapping of the human genome means it is now feasible to conduct large genome-wide linkage and association studies for complex behaviors and diseases. This textbook focuses on conducting genetic linkage and association analysis in the post-genomic era. It also covers established and new methodologies.
Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This title describes the genetic discoveries in relation to neural circuit development and activity. It explores topics in neural circuits and behavior research in zebrafish, drosophila, c elegans, and mouse models.
Aimed at graduate students and researchers and including statistical models and analytical procedures, this book introduces the basic concepts and methods used in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture and related fields.
The rapid progress in genomics and related technologies has increased interest in genetically modified organisms (GMOs). This book equips you with information about what genes are, how they work, and how they can be modified and used in biotechnology. On environmental genetics, it also considers the risks of releasing agricultural GM plants.
Aims to bring together the ideas and findings of data mining researchers and bioinformaticians by discussing research topics such as gene expressions; protein/RNA structure prediction; phylogenetics; sequence and structural motifs; genomics and proteomics; gene findings; drug design; RNAi and microRNA analysis; and more.
Presents original research results on the advances of genetics discovery. This title also presents and discusses varied topical data such as: genetic and biochemical markers of serotonergic and catecholaminergic systems in neuropsychiatric disorders; genetics and molecular biology of kainate receptors; and, others.
Presents research results of genetics discovery. This title discusses varied topical data such as cytogenic mapping of animal genomes; somatic cell counts in cow's milk and implications for dairy cow breeding; mutations and the carcinogenic process; and, genetic mapping projects and functional genomics.
Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This title describes the genetic discoveries in relation to neural circuit development and activity. It explores topics in neural circuits and behavior research in zebrafish, drosophila, c elegans, and mouse models.
Metagenomics is the study of microbial communities sampled directly from their natural environment, without prior culturing. DNA sequencing (or alternatively, an assay of functional properties) is applied to the culture-independent analyses of complex and diverse (meta) populations of microbes. This book studies metagenomics and its applications.
This book, published in cooperation with the International Society for Transgenic Technology, details methods that can be applied to the creation and analysis of genetically modified animals. Topics range from standard techniques to sophisticated methods.
The R language is available for a range of computer systems and has been adopted as a computational environment by many authors of statistical software. This book integrates a variety of data analysis methods into the R language. It also gives examples from real biological problems with an emphasis on how things work in an R package.
Investigation of Plant-Microbe Symbioses (PMS) is the developing area of modern biology. This book presents an analysis of PMS aimed at developing the Evolutionary Genetics of Plant-Microbe Symbioses which enables to reveal the general and specific mechanisms for evolution in different PMS types, and use the application of PMS in agrosystems.
Offers an overview of developments in the field of analytical applications for nucleic acids. This book covers various topics from fundamentals of functional nucleic acids, to their applications as sensors, to nanotechnologies; as well as integration of functional nucleic acids into practical analytical systems.
Population genetics is the study of the allele frequency distribution and change under the influence of the four evolutionary forces: natural selection, genetic drift, mutation and gene flow. It also takes account of population subdivision and population structure in space. This book presents the research in the field from around the globe.
The bestselling introduction to bioinformatics and functional genomics-now in an updated edition Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline.
This text introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level. Included are descriptions of molecular methods, as well as explanations of the relevant estimation theory using actual data.
Increasing number of complete genome sequences has enhanced our understanding of chromosomal basis of genetic inheritance to molecular level. This book presents the historical perspective as well as the journey from chromosomes to genome. It also presents complex topics in a simplified manner that is accessible to students of biology.
Mycorrhiza is a mutualistic association between fungi and the roots of the vast majority of terrestrial plants. In natural ecosystems, the plant nutrient uptake from the soil takes place via the extraradical mycelia of these mycosimbionts. This title reviews studies on symbiotic relevant gene functions.
In this second edition, distinguished contributors with extensive experience in the gene targeting and mouse genetics fields reveal a comprehensive set of step-by-step laboratory protocols and emphasize the new mutagenesis techniques developed in recent years.
Helps the reader get started in creating phylogenetic trees from protein or nucleic acid sequence data. This work leads the readers through identifying sequences that are homologous to a sequence of interest, downloading these sequences from databases, creating multiple alignments, and using several different methods to construct trees.
The authors bring together an array of theoretical and empirical applications of quantitative genetics in this work that is designed for anyone with a rudimentary understanding of statistics and genetics. Central concepts are developed from first principles and are illustrated with examples.
The rapid technological progress transforming the investigation of genetic variation within and between species makes this volume especially relevant. Its six sections cover advanced molecular biology protocols as well as providing an overview of the field.
Aims to offer scientists with the confidence to apply problem solving to the major principals of genetics. This title introduces them to the art of problem solving by integrating problems within each chapter. It presents a clear connection between key principals and related problems in each chapter.
Provides a broad view of epigenetics. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, this title presents the nature and applications of the science for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.
By implementing population structure as a practical forensics and clinical genomics tool, this title serves to redefine the way science and history look at ancestry and genetics. It shows how these tools can be used to maximize the efficacy of our criminal justice system.
Offers an articulate description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format. Suitable for students in biological sciences, this book is a restructured and expanded edition of "Latchman's Gene Regulation: A Eukaryotic Perspective, Fifth Edition".
Critically engages with the relational, moral and ethical issues surrounding genetic testing in contemporary society. In this book, competing accounts of autonomy, responsibility and blame - by families, by professionals and in the public sphere - are analysed rigorously within a discourse-rhetorical framework.
Aims to make population genetics approachable, logical and easily understood. To achieve these goals, this book emphasizes on well explained introductions to key principles and predictions. These are augmented with case studies as well as illustrations along with introductions to classical hypotheses and debates.
Focusing on the underlying principles of modern genetic analysis, this title provides the "how" and "why" of the essential analytical tools needed. The authors provide an easy guide to difficult genetic concepts, from mutation and gene function to gene mapping and chromosome segregation.
Offers an introduction to the field for biologists. This book features: Chapters on genomic databases, predictive methods using RNA sequences, sequence polymorphisms, protein structure prediction, intermolecular interactions, and proteomic approaches for protein identification.
Designed to enable researchers to design and undertake a phage display project, from designing an experimental strategy and constructing a library to performing selections and analyzing the results. The protocols and chapters in this book are cross-referenced, allowing readers to move beyond the specific examples provided.
An introductory genetics text that continues to build upon the integration of mendelian and molecular principles, providing students with the links between early genetics understanding and the molecular discoveries that have changed the way the field of genetics is viewed.
Identifying the key concepts and making connections among them, Pierce allows students to study the big picture of genetics. The 4th edition includes new coverage on epigenetics, the first synthetic organism, our relationship to Neanderthals, microRNAs, and updates to numbers, structures, and mechanisms.
Takes an experimental approach to understanding genetics. This book weaves one or two experiments into the narrative of each chapter to enable students to explore scientific methods and understand the genetic principles that have been learned from these experiments.
This volume summarizes the first era of genomic studies of aquaculture species in which the tools and resources necessary to support whole-genome sequencing were developed. These tools will enhance efforts toward selective breeding of aquaculture species.
Presents and discusses research in the field of genetics. This book covers topics that include gene regulation and early developmental gene expression in vertebrates; developmental regulation of sensory receptor gene expression; gene silencing; effective methods for selecting siRNA sequences; genetic diversity; and, more.
An accessible introduction to the field of genome science, it explains bioinformatic principles and experimental strategies alongside experimental methods. This edition has been updated to include the latest developments in next generation sequencing, high-volume genotyping and expression profiling, and advances in metabolomics.
It is the study of genetic variation, backed up by language and archaeology, which provides evidence about the spread of farming, the movements of peoples across the globe, the precise links between races - and the sheer unscientific absurdity of racism. This work offers an investigation into the past 100, 000 years of human history.
Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, this book is useful for undergraduates throughout their studies in molecular genetics. It puts genomes, rather than genes, at the centre of molecular genetics teaching.
The genogram is a graphic way of organising information gathered during a family assessment and identifying patterns in the family system. This text highlights developments in genogram use; explains how to draw, interprets and applies the genogram. It is suitable for introducing those involved in family treatment.
Mapping the worldwide geographic distribution of genes for over 110 traits in over 1800 primarily aboriginal populations, the authors charted migrations and devised a clock by which to date evolutionary history. This work shows where human populations originated and the paths by which they spread.
Authored by leading experts, this seminal text presents an account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It contains many examples and illustrations and is for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine.
RNA interference (RNAi) is a mechanism that inhibits gene expression by causing the degradation of specific RNA molecules or hindering the transcription of specific genes. RNAi targets include RNA from viruses and transposons, and also plays a role in regulating development and genome maintenance. This book presents the research in the field.
Explores the isolation and characterization of RNA-protein complexes, the analysis and measurement of RNA-protein interaction, and related novel techniques and strategies. This book includes brief introductions to the material, lists of necessary materials and reagents, step-by-step, and readily reproducible laboratory protocols.
Epigenetic means "on the gene, and the term refers to the recent discovery that stress in the environment can impact an individual's physiology so deeply that those biological scars are actually inherited by the next several generations. Epigenetics" is the first book for general readers on this fascinating and important topic.
This landmark volume provides the single most comprehensive and authoritative textbook on bacterial molecular genetics. Perfect for advanced undergraduate and graduate-level courses, the text presents the latest research on the subject in a clearly written and well-illustrated style.
Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This title describes the genetic discoveries in relation to neural circuit development and activity. It explores topics in neural circuits and behavior research in zebrafish, drosophila, c elegans, and mouse models.
A textbook for a graduate or advanced undergraduate course introducing basic concepts in population and quantitative genetics, including measuring selection on phenotypic characters. The focus is on methods applicable to field studies of ecologically important traits. Annotation 2004 Book News, Inc.
Presents a collection of tested laboratory protocols for the isolation and characterization of eukaryotic and prokaryotic RNA. This book emphasises on transcript profiling, including quantification issues and elucidation of alternative transcription start sites. It includes classic and contemporary techniques useful for labs.
Taking the phylogenetic tree as the central metaphor of evolution, this text develops a phylogenetically based approach to molecular evolution that aims to enable students to see both the evolutionary relevance of molecular data, and the relevance evolutionary theory has for molecular studies.
Takes readers inside the head of the kinds of malevolent people you know all too well, but could never understand. Starting with psychology as a frame of reference, this work uses images of the working brain to provide startling support for the idea that 'evil' people act the way they do mainly as the result of a dysfunction.
Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesisers allow the synthesis of oligonucleotides up to 160 to 200 bases. The length of a synthesised base is usually denoted by 'mer' (from 'Greek' meros "part"). This book brings research in the field from around the globe.
Brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist, this book shows how data from the post-genomic era can be used to examine human origins and the human colonisation of the planet.
Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. This book contains cutting-edge genome analysis methods from leading bioinformaticians.
Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This title describes the genetic discoveries in relation to neural circuit development and activity. It explores topics in neural circuits and behavior research in zebrafish, drosophila, c elegans, and mouse models.
Aiming to present the human animal in all its diversity, this work tells us who, why and how we are. It touches on themes such as sexuality, aggression, love, parenting, religion, ageing, and mental illness. It also ponders such topics as our need to seek out beauty; why our preferences in food become fixed; and more.
Intends to ask the questions: what are the universal properties of living systems, and how can one construct from there a phenomenological theory of life that leads naturally to complex processes such as reproductive cellular systems, evolution and differentiation?
Nominated for an American Book Award in Non-Fiction, this text traces the study and practice of eugenics - the science of "improving" the human species by exploiting theories of heredity - from its inception in the late 19th century through to the latest developments in genetic engineering.
Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma, and more, this new book offers a blend of new technologies and new insights in the fields of both pigmentation and mouse genetics. It includes some comparative information on other organisms as well.
The fact that living things inherit traits from their parents has been used since prehistoric times to improve crop plants and animals through selective breeding. This book gathers the research from around the globe focusing on such topics as: phylogeography of finches and sparrows, pig genomics and transgenesis in biomedical research, and more.
How did we, each of us, end up where we are? Why do we appear in such a wide array of different colours and features? This work unravels the slight changes in our DNA over time to tell the ancient story of our shared human journey. It also details the work of The Genographic Project.
Considers evolution at different scales: sequences, genes, gene families, organelles, genomes and species. Aimed at graduates and researchers in phylogenetics, mathematicians, computer scientists and biologists, this book of contributed chapters explains the basis and covers the results in this topical area.
Demonstrates the relevance of genetics with an integrated case-based approach. Suitable for non-science majors, this text shows student the importance of genetics by placing concepts within real-life contexts. It also shows students how and why the concepts of human genetics are vital to their personal lives and to society at large.
Steve Jones's highly acclaimed, double prize-winning, bestselling first book is now fully revised to cover all the new genetic breakthroughs from GM food to Dolly the sheep.'An essential sightseer's guide to our own genetic terrain.' Peter Tallack, Sunday Telegraph
Reflects the dynamic nature of modern genetics by emphasizing an experimental, inquiry-based approach with a treatment of many research experiments. This text is suitable for students who have had some background in biology and chemistry and who are interested in learning the central concepts of genetics.
Here are the most relevant ideas on the use of local, endogenous, and exogenous progenitor/stem cells to prevent and treat lung injury, from mesenchymal stem cells in lung repair to the effect of physical activity on mobilization of stem and progenitor cells.
In this study, Gehring describes his contributions to the discovery of the homeobox, a characteristic DNA segment found in the genes of all higher organisms, and explains how this has provided the key to our modern understanding of development and evolution.
Communicates the importance of genes and genomics studies in various aspects of life. This title bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease.
How do we identify the genes that make up our genome? And how do different genes form the regulatory networks that direct the process of life? This book provides an insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how a genome is constructed and how it operates; and more.
This book details the scope of RNA-based biology and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. Featuring high quality illustrations, it presents a range of RNA-based mechanisms that connect in the RNA infrastructure.
Phenotypic plasticity provides an important source of genetically based variation that can facilitate adaptive genetic differentiation between populations. This book explores this field from various sub disciplines, such as organismal ecology, developmental biology, genetics, behavioral ecology and evolutionary theory.
The Cell Biology of Stem Cells discusses multiple aspects of stem cell biology, ranging from the basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells. The cell biology of stem cells is discussed, in addition to the questions that still remain.
The sunflower has fascinated mankind for centuries. The oilseed sunflower contributes approximately ten per cent of the world's plant-derived edible oil. This title intends to bridge traditional research with modern molecular investigations on sunflower.
A primer of Population Genetics, third edition, provides a concise but comprehensive introduction to population genetics. The four chapters of the book address genetic variation, the causes of evolution, molecular population genetics and the genetic architecture of complex traits.
Describes the examples of protein/DNA/inorganic nanocomposite materials. This title provides a simple method for the binding of DNA to negatively charged solids, and such approaches aid in engineering more effective synthetic materials for gene-delivery, RNA-delivery and drug delivery applications.
A plain-English guide to genetics Want to know more about genetics? This non-intimidating guide gets you up to speed on all the fundamentals and the most recent discoveries. Now with 25 new and revised material, Genetics For Dummies, 2nd Edition gives you clear and accessible coverage of this rapidly advancing field.
Focuses on how a small socio-political American elite seeks to establish its control over the very basis of human survival, the provision of our bread. This book takes the reader inside the corridors of power, into the backrooms of the science labs, behind closed doors in the corporate boardrooms. It reveals government corruption and coercion.
This best-selling textbook, known for its prominent authorship, exposes students to the landmark experiments in genetics, teaching them how to analyze experimental data and draw their own conclusions based on scientific thinking. The 10th edition has been updated with key advances in genetics and cutting-edge experiments.
Deals with the bioinformatics of carbohydrates and glycoproteins. This book introduces the methods used for conformational analysis of carbohydrates. It describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. It offers an overview on bioinformatics tools facilitating analysis of carbohydrate structures.
Marsupial genetics and genomics research is more important than ever. This unique volume recounts some of the history of research in this field and highlights the most recent advances in the many different areas of marsupial genetics and genomics research.