Panadol Extra Soluble Tablets Panadol Extra Soluble Tablets provide relief from headache, migraine, back-ache, rheumatic pain, toothache & period pain. They also relieve sore throats & the fever, aches & pains of cold & flu. The active ingredients in Panadol Extra Soluble Tablets are paracetamol, a painkiller that also reduces your temperature when you have a fever & caffeine which increases the effectiveness of the paracetamol.