Panadol Advance 500mg Tablets Panadol Advance 500mg Tablets contain Optizorb technology which breaks down the active ingredient in the stomach up to five times faster than standard paracetamol tablets for fast, effective relief from headaches, toothache, back-ache, rheumatic & muscle pains & period pain. They also relieve the aches & pains of cold & flu, sore throat pain & help to reduce temperature. Panadol Advance 500mg Tablets can also be used to help to relieve the pain of mild arthritis which has been diagnosed by a doctor. The active ingredient in Panadol Advance 500mg Tablets is paracetamol, a painkiller & also reduces your temperature when you have a fever.