Panadol Extra Advance Tablets Panadol Extra Advance Tablets provide stronger pain relief than ordinary paracetamol tablets & thanks to their unique Optizorb technology, they work quicker than standard paracetamol & caffeine tablets too, starting to be absorbed in as little as 10 minutes & are even gentle on the stomach. Pandol Extra Advance Tablets relieve mild to moderate pain such as headache, migraine, back-ache, rheumatic pain, toothache & period pain. They also relieve the fever, aches & pains of colds & flu. The active ingredients in Panadol Extra Advance Tablets are paracetamol, a painkiller that also reduces your temperature when you have a fever & caffeine which increases the effectiveness of the paracetamol.