Panadol Night Pain Tablets Panadol Night Pain Tablets are used for the short term treatment of bedtime pain, for example headache, migraine, back-ache, rheumatic & muscle pain, neuralgia, toothache & period pain. As well as the painkiller paracetamol, they also contain diphenhydramine hydrochloride, an antihistamine that causes sleepiness or drowsiness. This makes it useful when your pain is keeping you awake.