Canesten Thrush Combi Pessary & External Cream Canesten Thrush Combi Pessary & External Cream is a complete treatment for vaginal thrush that treats both the internal cause of thrush & the external symptoms. The active ingredient in both the pessary & the cream is clotrimazole, an antifungal agent that fights the cause of vaginal thrush. The pessary treats thrush at the site of the infection, while the cream soothes the external itching. Women who suffer from recurrent attacks of thrush can also apply the cream to their male partner's penis, even if he has no symptoms of thrush, to reduce the frequency of attacks. Canesten Thrush Combi Pessary & External Cream should only be used if you have been previously diagnosed by your doctor as having vaginal thrush.