Canesten Thrush Combi Internal & External Creams Canesten Thrush Combi Internal & External Creams is a complete treatment for vaginal thrush that treats both the internal cause & the external symptoms. Both creams contain the active ingredient clotrimazole, an antifungal agent that fights the cause of thrush infections. The internal cream is supplied in a pre-filled applicator for quick & easy treatment at the site of the infection, while the external cream provides soothing relief from the external irritation caused by thrush. Canesten Thrush Combi Internal & External Creams should only be used if you have been previously diagnosed by your doctor as having vaginal thrush.