MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results & recommended guidelines, state-of-the art radiographic images, therapeutic approaches & specific treatments, hundreds of demonstrative full-color drawings, & practical clinical decision trees & algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology & clinical medicine, Harrison's Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice & education, the landmark 20th Edition
Features: Thoroughly revised content-covering the many new breakthroughs & advances in clinical medicine that have occurred since the last edition of Harrison's. Chapters on acute & chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, & many more, deliver the very latest information on disease mechanisms, diagnostic options, & the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison's focuses on pathophysiology with rigor, & with the goal of linking disease mechanisms to treatments. enhanced understanding of how diseases develop & progress not only promotes better decision-making & higher value care, but also makes for fascinating reading & enhanced retention. Harrison's summarizes important new basic science developments, such as the role of mitochondria in programmed & necrotic cell death, the immune system's role in cancer development & treatment, the impact of telomere shortening in the aging & disease processes, & the role of the microbiome in health & disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions & misfolded proteins in neurodegenerative diseases, & obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new & emerging areas of vital interest to all healthcare professionals. New sections include: Sex & Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, & Metabolic Syndrome; & Consultative Medicine- Plus, a new Part covering cutting-edge topics in research & clinical medicine

Includes:: great new chapters on the role of Epigenetics in Health & Disease, Behavioral Strategies to Improve Health, Genomics & Infectious Diseases, Emerging Neuro-Therapeutic Technologies, & Telomere Function in Health & Disease, & Network System Medicine. Important & timely new chapters-such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, & more-offer the very latest, definitive perspectives on must-know topics in medical education & practice. Updated clinical guidelines, expert opinions, & treatment approaches from world-renowned editors & authors contribute to the accuracy & immediacy of the text material & present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforc


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The Voice of Clinical Reason Harrison's Principles of Internal Medicine is the world's most trusted clinical medicine text-and a superb ...

This is the authority of Harrisons in a full-color, carry-anywhere presentation. " Harrisons Manual of Medicine, 18/e" is a distillation of the most clinically relevant content of " Harrisons Principles of Internal Medicine, 18/e". Presented in full color, this authoritative guide focuses on diagnosis & treatment, with an emphasis on patient care. This title provides on-the-spot answers to common clinical problems. It is completely updated to reflect the latest research & developments. It

Includes:: increased number of full-color illustrations.

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In Harrodsburg, Dougie Wallace looks at the excessive wealth & consumerism that can be found around the Knightsbridge area close to the world famous department store, Harrods. From the mid-1970s onwards, Gulf millionaires began coming to the area. They were later joined by the Oligarchs & the Hedgies, in a phenomenon that now involves all the various tribes of the global super-rich buying up London properties as if they were assets to appreciate in value rather than homes in which to live. The work is a powerful, timely & stark expose of the emergence of this ultra-affluent elite who are changing the face of the city, pricing out not just ordinary people but even the upper middle class natives of Central London, & marginalising old wealth from their time-honoured habitats. Employing his trademark wit & keen eye for the absurd, Wallace has produced an uncompromising & revealing series of pictures which draw attention to the excesses of the super rich in powerful & direct detail. Harrodsburg is introduced by cultural commentator Peter York, perhaps best known for his best-selling 1970’s classic The Official Sloane Ranger Handbook. Most recently, in November 2016 he presented Peter York's Hipster Handbook on BBC4. ...

This new title is the latest in the new series of Paul Hannon's walking guides. A range of enhancements see a more logical geographical spread featuring the countryside between Ilkley in the Wharfe Valley & Harrogate in the Nidd Valley. Included are the towns of Knaresborough, Otley & Wetherby, & the ever-popular Washburn Valley. This book

Includes:: sections of previous titles ` Harrogate & the Wharfe Valley' & ` Ilkley Moor'. All routes have been re-walked & updated, with the addition of several new walks. The walks include such iconic landmarks as Ilkley Moor, Almscliff Crag, Otley Chevin, Harewood & the Nidd Gorge. This book provides 25 enjoyable outings amid a rich variety of scenery. A collection of 40 colour photographs depict features & landscapes along the routes, while the concise route descriptions are complemented by a wealth of background information.

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Harrogate & Ripon, just a few miles apart in one of the most beautiful localities in Yorkshire, have rarely had their contributions to the Great War told all together, in one volume. Stephen Wade has written an account of their importance, from the Ripon camps, where thousands of infantrymen for Kitchener's new Pals' Battalions were trained, to the many Harrogate hospitals where casualties were cared for. Added to this are stories of local individuals, at home & in the European theatre of war, who played their part in this massive conflict. Harrogate & Ripon, made the usual contributions to the war effort, raising money & making food, but the local people experienced many of the significant Yorkshire events of the war, such as the explosion at Barnbow munitions factory & the housing of Belgian refugees. The book tells the stories of not only the heroes, such as Betty Stevenson & Donald Bell VC, but of the ordinary Yorkshire folk who endured the hardships & made great sacrifices. The book provides ample evidence that Harrogate & Ripon, along with their surrounding areas, have a fine record for courage & determination during the First World War. ...

" The Harrogate Great Chronicle" is a unique & new type of local book. Part I, the printed book, is a complete history of the crucial early development of the English Spa from its earliest documentary reference in 1322 to the Harrogate Improvement Act of 1841. In many ways it acts as a prequel to the late H.H. Walkers monumental " History of Harrogate under the Improvement Commissioners, 1841-1884". It is an evenly flowing narrative which is particularly concerned with the discovery, use & promotion of the mineral wells, whose health-giving powers became the foundation of Harrogates later prosperity. Along with the history of the spa, & the important role of the Duchy of Lancaster in urban development, Part I also considers the changing role of education, hospitals, schools, religion & the churches, local government & poor law, transport, social history, the enclosure movement & how national events such as plagues, revolution & war all affected life in one small Yorkshire town. The author has consulted virtually every original source of information, many of which are to found as far afield as London or Oxford, in order to produce a strikingly comprehensive & useful narrative. Uniquely, in Part II of the " Harrogate Great Chronicle" he has ordered virtually all of these source materials into 24 sections which
- because of their sheer size
- have been reproduced in digital form on a CD-ROM which is bound into the case of this hardback volume. The narrative history of Part I refers constantly to the source material in Part II, an approach which allows other readers to test the authors conclusions & which, importantly, provides local people with an absolutely vast source of information about the early history & development of their town. Local people & historians everywhere will find masses of new information & new insight in this unique publication. Part I in book form; Part II on CD-ROM is bound into the back of the case.

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Harrogate History Tour is a unique insight into the illustrious history of this famous Yorkshire spa town. This new book guides us through the streets & alleyways, showing how its famous landmarks used to look & how they've changed over the years as well as exploring its lesser-known sights & hidden corners. With the help of a handy location map, readers are invited to follow a timeline of events & discover for themselves the changing face of Harrogate. ...

Harrogate in 50 Buildings examines the architectural treasures of this famous Yorkshire spa town. Established local author Malcolm Neesam has selected fifty of Harrogate's most significant architectural & historical buildings & describes their provenance, design, materials & use. Many of Harrogate's important older buildings were created to serve the spa that developed after 1571, & the design of these buildings often reflected the visitors' needs for accommodation, spa treatments, entertainment & bodily exercise. The uniqueness of Harrogate largely derives from the spa associations of its buildings. More recently, with the decline of British spas, Harrogate has managed to continue to build innovative & interesting buildings that enrich the community's architectural heritage. Join author Malcolm Neesam as he explores Harrogate's finest architectural marvels in a new & accessible way. ...

Pay a visit to the fashionable spa town of Harrogate in this special edition of MONOPOLY. Harrogate is renowned for its rich mineral waters, intricate history & memorable landmarks & attractions
- all of which can be yours, if you can strike a deal. Explore some of Harrogate’s most beloved features, from Valley Gardens to the Harrogate Flower Show, the Pump Museum & the famous Bettys tea rooms. Each location has been specially selected for its local interest & universal appeal. The utilities & modes of transport in the game feature local services, & many spaces are inspired by popular local businesses for an authentic & modern experience. Who will be the first to claim Stockeld Park for their own? Maybe Harrogate Railway Station will bring you a step closer to success. Featuring stunning & authentic photography from the local area, there’s plenty to enjoy whether you’re a seasoned MONOPOLY expert or a first-time player. So grab a cup of tea, roll the dice & seek your fortune! 2-6 Players Age 8+
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