Lehninger Principles of Biochemistry has been a classroom favourite since its first edition. It is the classic introduction to biochemistry that brings clarity & coherence to an often unwieldy discipline a textbook on the fields classic core always made fresh by combining the fields definitive advances with an admirable ability to reach students. In addition to content updates throughout & more emphasis on medical relevance the fifth edition provides updated pedagogy that supports lecturers in addressing key challenges in teaching the biochemistry course. NEW TO THIS EDITION INCLUSION OF MAJOR ADVANCES IN BIOCHEMISTRY Every chapter has been thoroughly updated to include the most important advances in biochemistry e.g.: * New discussion of amyloid diseases in the context of protein folding (Chapter 4) * Expanded & updated section on lipid rafts & caveolae to include new material on membrane curvature & the proteins that influence it & introducing amphitropic proteins & annular lipids (Chapter 11) * New Box 24-2 Epigenetics Nucleosome Structure & Histone Variants describing the role of histone modification & nucleosome deposition in the transmission of epigenetic information in heredity BIOCHEMICAL METHODS Understanding of biochemistry & its practical application is increased with new & updated details on the methods used to obtain information e.g.: * Use of MALDI-MS in determination of oligosaccharide structure (Ch. 7) * Use of tags for protein analysis & purification (Ch. 9) MEDICALLY RELEVANT EXAMPLES An icon is used throughout to denote material of medical interest. Many new examples have been included that relate biochemistry to medicine & to health issues in general. The authors goal is for students to learn biochemistry & to understand its relevance to life & the planet. SPECIAL THEME: UNDERSTANDING METABOLISM THROUGH OBESITY & DIABETES Obesity & its medical consequences-cardiovascular disease & diabetes-are fast becoming epidemic in the industrialized world & this edition

Includes:: new material on the biochemical connections between obesity & health throughout the book. This focus on diabetes provides an integrating theme throughout the chapters on metabolism & its control. NEW PROBLEM-SOLVING TOOLS * New in-text Worked Examples help students improve their quantitative problem-solving skills taking them through some of the most difficult equations. * More than 100 new end-of-chapter problems give students further opportunity to practice what they have learned. * New Data Analysis Problems (one at the end of each chapter) encourage students to synthesize what they have learned & apply their knowledge to the interpretation of data from the literature. FOCUS ON ORGANIC CHEMISTRY FOUNDATIONS This helps students understand biochemistry by drawing on what they learned in their Organic Chemistry module. * New Section 13.2 Chemical Logic & Common Biochemical Reactions discusses the common biochemical reaction types that underlie all metabolic reactions. * Chemical logic is reinforced in the discussions of central metabolic pathways. * Mechanism figures feature step-by-step descriptions to help students understand the reaction process. * In the presentation of reaction mechanisms the book consistently uses a set of conventions introduced & explained in detail with the first enzyme mechanism encountered. * Some of the new problems focus on chemical mechanisms & reinforce mechanistic themes. KEY CONVENTIONS MADE CLEAR Many of the conventions that are so necessary for understanding each biochemical topic & the biochemical literature are broken out of the text & highlighted. These Key Conventions include clear statements of many assumptions & conventions that students are often expected to assimilate without being told (for example peptide sequences are written from amino- to carboxyterminal end left to right; nucleotide sequences are written from 5 to

...

Perfect for day trips & short breaks the OS Landranger Map series covers Great Britain with 204 detailed maps. Each map provides all the information you need to get to know your local area &

Includes:: places of interest tourist information picnic areas & camp sites plus Rights of Way information for England & Wales.

...

OS Explorer Map is the Ordnance Survey's most detailed map & is recommended for anyone enjoying outdoor activities like walking horse riding & off-road cycling. Providing complete GB coverage the series details essential information such as youth hostels pubs & visitor information as well as rights of way permissive paths & bridleways. ...

This work talks about the Midland main line from Loughborough to Market Harborough; Midland lines from Leicester (West Bridge); Lines around Melton Mowbray; LNWR lines to Loughborough (Derby Road) & Hinckley; GNR & LNWR Joint line from Bottesford to Hallaton & Leicester (Belgrave Road); & Great Central line from Loughborough to Lutterworth. ...

Leigh Bowery (1961-1994) was a performance artist fashion designer nightclub sensation art object aspiring pop-star & above all an icon whose influence traversed the music art film & fashion worlds. Perhaps he is best-known for his role as muse & nude model for some of Lucian Freuds most famous paintings: ironic for the man who was infamous for his costumes. Bowery arrived in London in 1980 from Sunshine Australia notoriously collaborated with dancer Michael Clark & was proprietor of the infamous 1980s nightclub Taboo. In the 1990s Leigh Bowery created performances which both delighted & outraged audiences in New York London & Tokyo later incorporating his pop group Minty. This book is the definitive guide to the looks designed & in these photographs worn by Leigh Bowery. One of Britains most heroically ambitious yet underappreciated designers & performance artists Bowery remains an inspiration to many contemporary fashion designers though few are willing to admit it. In Leigh Bowery Looks you can easily see why: it contains more than 150 previously unpublished photographs of Bowery an extraordinary body of work that was the outcome of his collaboration with British photographer Fergus Greer between 1988 & 1994 the year of Bowerys death. ...

Leiths Meat Bible" is the ultimate meat cookbook. Packed with recipes from all over the world it has something for every occasion from a simple after-work supper to an elegant dinner. As with every book from the Leiths series all recipes are foolproof with an emphasis on proper technique. The first part of the book guides you through the basic techniques for choosing preparing cooking & carving meat including an illustrated guide to the different cuts of meat (and how to tell if a piece of meat is fresh & good-quality) advice on how to handle & store raw meat & easy-to-follow instructions on every kind of cooking method you will need. Following this are chapters on each type of meat including delicious recipes ranging from the classics such as Beef stew Shepherds pie Slow-roast pork belly & Toad-in-the hole to more adventurous dishes such as Sticky chicken goujons with caramelised lemons Duck breasts with blackberry & apple sauce & Thai basil pork. There are also tempting & inventive ideas for cooking with cheaper cuts of meat. This huge book

Includes:: full colour photographs illustrated techniques tips wine recommendations for every recipe troubleshooting guides a glossary of cooking terms & much more. Utterly comprehensive reliable & easy to use this is an essential book for every kitchen."

...

The Leiths cookery series are the most useful books to have in your kitchen. Produced by the acclaimed Leiths School of Food & Wine they are the most authoritative thorough & comprehensive cookbooks you can have. Leiths Baking Bible covers every aspect of baking from bread patisserie & pastry to cakes scones buns & biscuits. You will find all the classic recipes here
- Profiteroles Quiche Lorraine Swiss Roll Brioche- & innumerable tempting alternatives
- Artichoke & Green Olive Tart Walnut Bread Almond Shortbread. As with all the cookbooks in the Leiths series the emphasis is on proper technique to ensure success everywhere. Both the ultimate reference book & a fantastic source of inspiration Leiths Baking Bible will be the only book you'll need for home baking.

...

The LEITH'S COOKERY BIBLE is a classic. The most authoritative & comprehensive cookbook there is for seasoned cooks & beginners chefs & caterers from the celebrated Leiths School of Food & Wine. Covering soups first courses vegetable dishes salads main courses stocks sauces dips spreads puddings cakes breads biscuits preserves canapes snacks & garnishes the Leiths Cookery Bible is truly exhaustive. In it you will find a perfected recipe for almost any dish you are looking for
- Steak Tartare Beef Bourguignonne Peking Duck Gazpacho Dauphinoise Potatoes Chicken Kiev Thai Red Curry Cassoulet
- & for any occasion be it a quick supper or cocktail party picnic three course meal or afternoon tea. The 1 400 recipes range from timeless classics such as Cheese Souffle & Steak & Kidney Pie to more innovative recipes such as Salmon & Plaice Ravioli & Red Onion & Polenta Tart & come from every part of the world from Scotland to the South Pacific. In addition there are clear illustrated instructions on how to perform every culinary operation from preparing a game bird to skinning a squid. From the prestigious Leiths School of Food & Wine this is a comprehensive & authoritative cookbook that contains everything anyone could ever need or wish to know in the kitchen.

...

Perfect for beginners in the kitchen & everyone who is time-pressed but would still like to eat tasty homemade food this is the ultimate cookery reference book. Leiths Simple Cookery Bible contains a colossal 700 recipes that are foolproof delicious easy to follow & utterly reliable. Covering soups tarts snacks & sandwiches salads main courses accompaniments puddings baking preserving drinks breakfasts & the all-important basic recipes this terrifically comprehensive book has every recipe you'll ever need from spaghetti Bolognese sausage hotpot or shepherd's pie to salmon with dill & mustard crust couscous stuffed peppers or sweet chilli beef. Recipes come complete with 'prepare ahead' instructions in case you want to cook them in advance making it easy to rustle up quick after-work suppers or to cook for friends & family without spending all your time slaving in the kitchen. They can be adapted to whatever you have in your cupboard at home (the book contains a special section on substituting ingredients) they can be made with convenience ingredients (like ready-rolled pastry & bought pesto which come with recommendations on the best brands to choose) & the 'basic' recipes contain delicious variations that will enliven every meal. With 100 colour photographs conversion tables a glossary of terms illustrated techniques tips (from whipping cream to cutting a mango) a guide to wines & cheeses a seasonal table of fruit & veg & much more this is the cookery book you will turn to every day. It is a collection of recipes for real life & one with inspirational ideas that will make ready-meals a thing of the past. ...

Leith Techniques Bible is the ultimate cookery reference book. Here you will find all the information taught during the year-long diploma course at Leiths School of Food & Wine. Learn how to prepare meat & fish make perfect pastry & bread as well as equip a kitchen. Understand what makes recipes work & what has happened when they haven't. With answers to every cookery question from how to make perfect mashed potatoes to making a spun sugar cage this is an indispensable book for everyone from the novice cook to the experienced chef. ...