Passengers boarding the 1035 train from Manchester Piccadilly to London Euston are bound for work assignations reunions holidays or new starts with no idea that their journey is about to be brutally curtailed Holly has just landed her dream job which should make life a lot easier than it has been & Jeff is heading for his first ever work interview after months of unemployment They end up sitting next to each other Onboard customer service assistant Naz dreams of better things as he collects rubbish from the passengers & among the others travelling are Nick with his young family who are driving him crazy; pensioner Meg & her partner setting off on a walking holiday & facing an uncertain future; Caroline run ragged by the competing demands of her stroppy teenage children & her demented mother; & Rhona unhappy at work & desperate to get home to her small daughter & in the middle of the carriage sits Saheel carrying a deadly rucksack