Having survived the violence & turmoil of his previous existence, Luc Deveraux (Jean-Claude Van Damme) has started a family & is working as a technical consultant on the Universal Soldier programme. The new generation of cyborg soldiers are overseen by the S.E.T.H. supercomputer & are even more deadly than before. Danger arises when S.E.T.H. becomes sentient & tries to negate Deveraux by kidnapping his daughter. With his family at stake, the Universal Soldier must return into action.