A synergistic blend of B vitamins with larger balance of niacinamide to niacin. Hypersensitivity to any of the constituent ingredients. Withdraw if Niacin flush occurs. Use Niacinamide or Niasafe as alternative. Contra-Indications If pregnant or breast feeding, consult your health care practitioner before using. For more information on this product contact your healthcare practitioner. This product should not be used as a substitute for a varied diet. Directions Recommended dose 1 capsule per day with a meal. Do not exceed this recommended dose unless prescribed by your practitioner.