Written by Brian K. Vaughan; Art by Pia Guerra & Jose Marza Jr.; Painted Cover by J.G. Jones When a plague of unknown origin instantly kills every mammal with a Y chromosome unemployed & unmotivated slacker Yorick Brown suddenly discovers that he is the only male left in a world inhabited solely by women. Accompanied by his mischievous monkey & the mysterious Agent 355 Yorick embarks on a transcontinental journey to find his girlfriend & discover why he is the last man on Earth. But with a gang of feminist extremists & the leader of the Israel Defense Forces hunting him Yorick's future as well as that of the human race may be short-lived.