In the seven years since the publication of Principles & Practice of Bioanalysis bioanalytical methods have remained the same but their usage patterns have changed. This second edition of a bestseller provides an updated guide to the techniques used in developing & running ultra-trace analyses for drugs metabolites & other substances. Extensively revised this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Each chapter has been overhauled or re-written to reflect modern practice. Experts in the field offer a logical path through the problems of small molecule bioanalysis enabling you to choose the appropriate methods of analysis across a number of fields including the agrochemical & pharmaceutical industries. They cover a wide range of analytical methods including mass spectrometry liquid chromatography immunoassay NMR & gas chromatography. Presenting the information in an informal & highly accessible style the book covers the theory & practice of bioanalysis enabling you to gain maximum benefit & to optimize analytical methods. With practical advice & guidance it delineates how to develop robust analytical methods for a range of compounds both natural & synthetic. Using these insights you can more easily recognize problems & quickly solve them.