Merging with a bizarre spiritual force called Genesis Texan Preacher Jesse Custer becomes completely disillusioned with the beliefs that he had dedicated his entire life to. Now possessing the power of the word " an ability to make people do whatever he utters Custer begins a violent & riotous journey across the country. Joined by his gun-toting girlfriend Tulip & the hard drinking Irish vampire Cassidy the Preacher loses faith in both man & God as he witnesses dark atrocities & improbable calamities during his exploration of America."