Set among the apple orchards of rural Maine it is a peverse world in which Homer Wells odyssey begins. As the oldest unadopted offspring at St Clouds orphanage he learns about the skills which one way or another help young & not-so-young women from Wilbur Larch the orphanages founder -- a man of rare compassion & an addiction to ether. Dr Larch loves all his orphans especically Homer Wells. It is Homers story we follow from his early apprenticeship in the orphanage surgery to his adult life running a cider-making factory & his strange relationship with the wife of his closest friend.