The Development of Chronic Pain Course In this course we look at the development of chronic pain. We start by looking at how different types of pain are transmitted: in particular, we look at the role played by peripheral sensitisation & hyperalgesia in transmitting chronic pain. We then consider the role of a range of chemical mediators in transmitting pain. Next, we look at drugs that relieve pain by sensitising the nociceptors. Finally, we consider the issue of central sensitisation to pain, & consider the problem of peripheral nerve damage.