For many people taking some form of medication is part of everyday life whether for mild or severe illness acute or chronic disease to target infection or to relieve pain However for most it remains a mystery as to what happens once the drug has been taken into the body how do the drugs actually work? Furthermore by what processes are new drugs discovered & brought to market? An Introduction to Medicinal Chemistry sixth edition provides an accessible & comprehensive account of this fascinating multidisciplinary field Assuming little prior knowledge the text is ideal for those studying the subject for the first time Part one of the book introduces the principles of drug action via targets such as receptors & enzymes The book goes on to explore how drugs work at the molecular level (pharmacodynamics) & the processes involved in ensuring a drug meets its target (pharmacokinetics) Further sections cover the processes by which drugs are discovered & designed & what has to happen before a drug can be made available to the public The book concludes with a selection of current topics in medicinal chemistry & a discussion of various key drug groups The subject is brought to life throughout by engaging case studies highlighting particular drugs & the stories behind their discovery & development The Online Resource Centre features For students Multiple Choice Questions to support self-directed learning Web articles describing recent developments in the field & further information on topics covered in the book Journal Club to encourage students to critically analyse the research literature Molecular Modelling Exercises with new exercises in Chem 3D New assignments to help students develop data analysis & problem solving skills For registered adopters of the book A test bank of additional multiple-choice questions with links to relevant sections in the book Answers to end-of-chapter questions Figures from the book ready to download Power Point slides to accompany every chapter in the book ...

DNA can be extracted & sequenced from a diverse range of biological samples providing a vast amount of information about evolution & ecology The analysis of DNA sequences contributes to evolutionary biology at all levels from dating the origin of the biological kingdoms to untangling family relationships An Introduction to Molecular Evolution & Phylogenetics presents the fundamental concepts & intellectual tools you need to understand how the genome records information about evolutionary past & processes how that information can be "read" & what kinds of questions we can use that information to answer Starting with evolutionary principles & illustrated throughout with biological examples it is the perfect starting point on the journey to an understanding of the way molecular data is used in modern biology Online Resource Centre The Online Resource Centre features For registered adopters of the book
- Class plans for one-hour hands-on sessions associated with each chapter
- Figures from the textbook to view & download

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An Introduction to Parallel Programming is the first undergraduate text to directly address compiling & running parallel programs on the new multi-core & cluster architecture It explains how to design debug & evaluate the performance of distributed & shared-memory programs The author Peter Pacheco uses a tutorial approach to show students how to develop effective parallel programs with MPI Pthreads & Open MP starting with small programming examples & building progressively to more challenging ones The text is written for students in undergraduate parallel programming or parallel computing courses designed for the computer science major or as a service course to other departments; professionals with no background in parallel computing ...

The second edition of this popular textbook builds on the strengths of the first continuing its reputation for clarity accessibility conceptual sophistication & panoramic coverage of personality & intelligence The authorship team is enriched by the addition of two high-profile international scholars Luke Smillie & John Song whose expertise broadens & deepens the text New to this edition Chapters exploring the neurobiological genetic & evolutionary foundations of personality; & emotion motivation & personality processes An enhanced coverage of personality disorders A thoroughly revised & extended section on intelligence which now addresses cognitive abilities & their biological bases; the role of intelligence in everyday life; & emotional intelligence A brand new companion website that

Includes:: a substantial test bank & lecture slides An Introduction to Personality Individual Differences & Intelligence Second Edition is a key textbook for all psychology students on a personality or individual differences course

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This highly respected & best-selling textbook provides an accessible engaging & comprehensive introduction to the major topics within physical geography It focuses on understanding the inter-linkages between processes places & environments & is comprehensively illustrated to demonstrate how the physical environment works Now in its fourth edition the book has been thoroughly updated throughout to contain the latest research Between them the contributors have researched in detail every environment on the planet providing an unrivalled source of rich information from around the world for both undergraduate & postgraduate study in the field of physical geography An Introduction to Physical Geography & the Environment is accompanied by a rich & extensive range of electronic support resources including updated weblinks relevant for each chapter an extended & annotated further reading list for each chapter multiple choice questions fieldwork exercises & interactive models ...

Why should some have the right to political power? What would happen without government? How much power should the state have? This is the ideal introduction to political philosophy combining clarity & a conversational style with a thought provoking account of the central questions in political philosophy Wolff explores the subject through a series of enduring & timeless questions jumping centuries & millennia to explore the most influential answers & demonstrate the relevance of political philosophy for an understanding of contemporary issues The eagerly anticipated new edition has been updated to include the on-going developments in theorising about race sexual orientation disability multiculturalism & global justice ...

The worlds of Wall Street & The City have always held a certain allure but in recent years have left an indelible mark on the wider public consciousness & there has been a need to become more financially literate The quantitative nature of complex financial transactions makes them a fascinating subject area for mathematicians of all types whether for general interest or because of the enormous monetary rewards on offer An Introduction to Quantitative Finance concerns financial derivatives
- a derivative being a contract between two entities whose value derives from the price of an underlying financial asset
- & the probabilistic tools that were developed to analyse them The theory in the text is motivated by a desire to provide a suitably rigorous yet accessible foundation to tackle problems the author encountered whilst trading derivatives on Wall Street The book combines an unusual blend of real-world derivatives trading experience & rigorous academic background Probability provides the key tools for analysing & valuing derivatives The price of a derivative is closely linked to the expected value of its pay-out & suitably scaled derivative prices are martingales fundamentally important objects in probability theory The prerequisite for mastering the material is an introductory undergraduate course in probability The book is otherwise self-contained & in particular requires no additional preparation or exposure to finance It is suitable for a one-semester course quickly exposing readers to powerful theory & substantive problems The book may also appeal to students who have enjoyed probability & have a desire to see how it can be applied Signposts are given throughout the text to more advanced topics & to different approaches for those looking to take the subject further

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This concise accessible introduction to quantum computing is aimed at advanced undergraduate & beginning graduate students from a variety of scientific backgrounds The text is technically detailed & clearly illustrated throughout with diagrams & exercises 288 pages numerous line drawings Kaye Phillip (Institute for Quantum Computing University of Waterloo Ontario Canada) ...

An Introduction to Quantum Field Theory is a textbook intended for the graduate physics course covering relativistic quantum mechanics quantum electrodynamics & Feynman diagrams The authors make these subjects accessible through carefully worked examples illustrating the technical aspects of the subject & intuitive explanations of what is going on behind the mathematics After presenting the basics of quantum electrodynamics the authors discuss the theory of renormalization & its relation to statistical mechanics & introduce the renormalization group This discussion sets the stage for a discussion of the physical principles that underlie the fundamental interactions of elementary particle physics & their description by gauge field theories ...

In an age of big data data journalism & with a wealth of quantitative information around us it is not enough for students to be taught only 100 year old statistical methods using 'out of the box' software They need to have 21st-century analytical skills too This is an excellent & student-friendly text from two of the world leaders in the teaching & development of spatial analysis It shows clearly why the open source software R is not just an alternative to commercial GIS it may actually be the better choice for mapping analysis & for replicable research Providing practical tips as well as fully working code this is a practical 'how to' guide ideal for undergraduates as well as those using R for the first time It will be required reading on my own courses- Richard Harris Professor of Quantitative Social Science University of Bristol R is a powerful open source computing tool that supports geographical analysis & mapping for the many geography & non-geography' students & researchers interested in spatial analysis & mapping This book provides an introduction to the use of R for spatial statistical analysis geocomputation & the analysis of geographical information for researchers collecting & using data with location attached largely through increased GPS functionality Brunsdon & Comber take readers from zero to hero' in spatial analysis & mapping through functions they have developed & compiled into R packages This enables practical R applications in GIS spatial analyses spatial statistics mapping & web-scraping Each chapter
Includes: Example data & commands for exploring it Scripts & coding to exemplify specific functionality Advice for developing greater understanding
- through functions such as locator () View () & alternative coding to achieve the same ends Self-contained exercises for students to work through Embedded code within the descriptive text This is a definitive 'how to' that takes students
- of any discipline
- from coding to actual applications & uses of R



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