Paul (Sean Penn) has less than a month to live he&s on the waiting list for a heart transplant & his wife (Charlotte Gainsbourg) is determined to get pregnant with his child before it&s too late Meanwhile Cristina (Naomi Watts) is a happy mother with a loving husband & two daughters but she loses her family in an instant to an unpredictable accident Finally Jack (Benicio Del Toro) is an ex-con & born-again Christian struggling to support his wife & two children while battling his own guilty conscience When these three parties come together explosively they make each other behave in impulsive violent & destructive ways 21 Grams takes the viewer on a jolting journey through sickness suffering morality revenge & last but not least the sometimes welcome peace of death