Evomuse Sleephoria 60 Caps Description Sleep & Diet are two of the core fundamentals of a happy & productive life. Much like a bad diet will run down your energy, bring on health problems, & make your appearance suffer, a low quality sleeping regimen will do much the same only worse. Chronic sleep problems hinder your body’s ability to renew itself, cripples your immune system, & causes stress hormones to skyrocket. Sleephoria is defined as that state of euphoria that arises when you get a solid, restful night of sleep…and for many of us that suffer from sleep problems, it is most certainly bliss. Sleep, as we well know, is essential to ideal health, recovery, growth, & optimal performance. The Sleephoria formula has been painstakingly tested & researched to provide a flawless night of sleep, allowing the body & mind to restore itself, without any residual hangover or difficulty waking up the next morning. For those suffering from occasional or chronic sleeping problems, current solutions are limited & somewhat undesirable. Prescription medications are undoubtedly effective, but can bring with them inconvenience, cost, & some undesirable effects. Over-the-counter sleep aids have been highly limited in the past – often accompanied by a hazy hangover the next morning that could take hours, as well as stimulants, to break. This cycle of taking a sleep aid, then a stimulant in the morning to counter the effect, can cause a vicious cycle. People have been craving natural solutions to sleep problems, & we took on the challenge: create a potent sleep aid that will gently carry you off to sleep, allow you to dream normally, increase the recovery effect from sleep, & all this without leaving you with a hangover in the morning. Ladies & gentlemen I present to you… Sleephoria. Due to the long list of ingredients in this formula, we will not be looking at an exhaustive review of the literature on each particular ingredient & all of its functions, instead we will present only the most relevant information relating to sleep, sedation & anxiety for the sake of brevity. However, it should be known that most if not all of the ingredients in Sleephoria have farther reaching effects on overall health & longevity than we have taken the time to dive into in this write up, & we encourage the more curious, science-minded readers to take a look at the more extensive research. But before we get too deeply into the individual ingredients, let’s discuss the GABA system. GABA is the primary inhibitory neurotransmitter. It tends to reduce exciteability in the central nervous system & help to bring on states of relaxation. So why not simply use GABA? Well, it’s complicated but mostly because the control of sleep states is central, while GABA tends not to be able to cross the blood brain barrier. Ideally, we want to activate GABA receptors while preventing its breakdown for as long as possible during the main period of sleep. So with that background, let’s get into the ingredients. Sleephoria... Arise & Conquer! Ingredient Overview: Coriandrum Sativum (standardized to 1% linalool) Where does it come from? Linalool is an aromatic chemical found in Coriander, as well as many other plants. Different aromas & neural effects can be expected from different sources of linalool, Coriandrum Sativum (CS) was selected for Sleephoria in part because of its linalool content but also due to other inherent properties relative to sleep & relaxation. What is it going to do for me?CS has been shown in animal studies to have anti-anxiety, sedative, muscle relaxant, & sleep prolonging qualities. Magnolia extract (80% Magnolol/ Honokiol) Where does it come from? The polyphonic compunds magnolol & honokiol come from the bark of the magnolia officinalis tree found in China where they have been widely used in Traditional Chinese Medicine. What is it going to do for me? Research shows that magnolia acts strongly on the GABA (A) receptor, causing decreased sleep latency (time required to fall asleep), & increased quality of sleep (). Based on its specific mechanism of action, it has been deemed to be likely effective for use as a sedative as well as an anti-anxiety agent Ganoderma lucidum (Ling Zhi) Where does it come from? Ling Zhi means 'supernatural mushroom', & has been used in Traditional Chinese Medicine for 2, 000 years to treat various ailments. What is it going to do for me? Most of the available research on this compound centers around immunomodulation, however; several studies have shined a spotlight on its ability to act as a hypnotic agent, promoting sleep through interaction with the GABA receptor. Crocin (30% extract) Where does it come from? Crocin is a natural carotenoid found in certain flowers. What is it going to do for me?, Crocin has been used successfully in Traditional Chinese Medicine for insomnia & anxiety (). A recent study out of Japan demonstrated that Crocin was able to significantly increase the amount of non-REM sleep measured over a four-hour period. Withania somnifera/ Ashwaghanda (2.5% extract) Where does it come from? Ashwagandha is a shrub in the nightshade family, harvested in various regions of India. What is it going to do for me? Ashwagandha is an extremely well studied compound with numerous studies supporting its use as an anti-anxiety agent. It has also been studied in conjunction with diazepam to improve sleep quality in a sleep disturbed state (, ). Ferulic acid Where does it come from? Ferulic acid is a phytochemical found in cell walls of plants, as well as in the seeds of artichokes, coffee, apples, peanuts & oranges. What is it going to do for me?A recent study out of China demonstrated that Ferulic Acid shortened sleep latency & had a sedative-hypnotic effect, acting through serotonin signaling modulation.. Matricaria recutita (chamomile) extract Where does it come from? Chamomile is a flower widely grown all over Europe, Asia, Australia & North America. What is it going to do for me? This ingredient was chosen for it's anti-anxiety properties. A controlled trial published in the Journal of Clinical Psychopharmacology found Chamomile to have anxiolytic effects in patients with Generalized Anxiety Disorder (GAD), & another study done out of Ottawa concluded that Chamomile showed significant inhibition of GAD effects through GABA modulation. Melissa officinalis L. (lemon balm) extract Where does it come from? Melissa officinalis is an herb in the mint family, originating in Europe. What is it going to do for me? By inhibiting GABA transaminase (an enzyme that breaks down GABA), Lemon Balm has shown an ability to dampen anxiety & promote a relaxed state in multiple studies. Stepholidine Where does it come fromstepholidine is a naturally occurring chemical found in the Stephania intermedia herb. What is it going to do for me? New research has elucidated Stepholidine as 'the first compound found to have a dual function as a dopamine receptor D1 agonist & D2 antagonist' (). It has also been shown to interact with the 5-HT (1A) receptor, which deals with serotonin (). A paper published in the journal Pharmacology Biochemistry & Behavior highlighted stepholidine as a treatment for insomnia, due to its ability to initiate & maintain NREM sleep.2-bromomelatonin Where does it come from? Melatonin is a hormone produced in the pineal gland of animals, & is also found in plants. 2-bromomelatonin is a brominated version of melatonin with about 10x higher receptor binding affinity over regular melatonin (). What is it going to do for me? Melatonin is widely accepted as an effective over the counter sleep aid. The brominated version is a supercharged cousin of the original. A study published in the journal Anesthesia & Anelgesia stated that it can exert hypnotic effects similar to Propofol, which is a powerful intravenous sedative administered in hospitals Sinapic acid Where does it come fromsinapic acid is found in high bran cereal grains & various herbal materials. What is it going to do for me? Through GABA (A) modulation, sinapic acid promotes relaxation & sedation. Results of a paper published in the journal Life Sciences concluded sinapic acid '…is a prominent anxiolytic agent, & its anxiolytic-like effects are mediated via GABA (A) receptors…'. Valerinic Acid Where does it come from? Valerian is one of the most well known & widely used over the counter herbs for inducing relaxation & sedation. Valerinic acid is a constituent of the essential oil of Valerian, believed to be responsible for much of the desired effects. What is it going to do for me? Valerinic acid (VA) is another ingredient in the Sleephoria formula that acts on the GABA (A) receptor to induce sedation (). In addition to its GABA activity, VA also partially agonizes the 5-HT (5a) receptor, once again involving serotonin. Numerous studies have found valerian & valerinic acid to improve sleep latency, quality of sleep, & induction of sleep (, , , , ).SUMMARYSleephoria will help eliminate the barriers to restful & regenerative sleep – whether stresses from everyday life, overactive brain activity at the improper time, or other causes by triggering a sedated, tranquil state of mind & a body ready to float away. You have used other, lesser effective sleep formulas in the past with little success or a nasty hangover in the morning…now try the formula that has no equal. Try the formula that, after two years in the making, is the most potent sleep-aid currently on the market. Try the formula that will bring you what you r body & mind need….euphoric sleep.