Prissy, refined Lauren (Shelley Long) thinks she has nothing at all in common with loud, brassy Sandy (Bette Midler)... until she discovers that they share the same boyfriend (Peter Coyote)! When their two-timing beau then goes missing, the unlikely duo are forced to reluctantly join forces & track him down. On the subsequent cross-country trek the women learn that complete opposites can sometimes get along after all.