Psychologist Helen Hudson (Sigourney Weaver) & detective M.J. Monahan (Holly Hunter) team up to track down a serial killer who is imitating famous murderers, one by one. Hunter's boss is not keen on her working with Weaver, who is herself confined to her apartment by agoraphobia. When the killer becomes aware that the pair are on his trail, he places them at the top of his hit list.