As people age, systemic inflammation can inflict degenerative effects throughout the body.1-5 A primary cause of this destructive cascade is the production of cell-signaling chemicals known as inflammatory cytokines. Along with these dangerous cytokines, imbalances of hormone-like messengers called prostaglandins & leukotrienes also contribute to inflammatory processes.6-8 The typical American diet is loaded with foods that contain arachidonic acid (like egg yolk, red meat, poultry, & dairy products) or stimulate the production of excess arachidonic acid in the body (foods rich in high-glycemic carbohydrates, saturated fats, & omega-6 fatty acids). Scientific studies show that excess arachidonic acid increases levels of the 5-lipoxy-genase (5-LOX) enzyme, which can induce undesirable effects in cells. This may result in the excess accumulation of leukotriene B4, a pro-inflammatory compound that attacks the joints, the arterial wall, & other tissues. In India, extracts from the Boswellia plant have been used for centuries as fluid-balancing agents.71 Human studies have confirmed that a specific Boswellia extract known as AKBA (3-O-acetyl-11-keto-&223;-boswellic acid) selectively inhibits 5-LOX.72 Unlike other boswellic acids that only partially inhibit 5-LOX, 72, 73 AKBA binds directly to 5-LOX, effectively suppressing its pro-inflammatory activity. A recent study indicated that 5-LOXIN&174; may exert its beneficial effects by controlling inflammatory responses through reducing pro-inflammatory modulators, & it may improve joint health by reducing the enzymatic degradation of cartilage. A 90-day, double-blind, randomized, placebo-controlled study demonstrated 5-LOXIN&174; reduces joint discomfort & improves physical functioning significantly in human subjects.74 References Supplement Facts Serving Size 1 capsule Servings Per Container 100 Amount Per Serving 5-LOXIN&174; [std. for acetyl-11- keto-&223;-boswellic acid (AKBA) minimum 30% on dried basis (22.5 mg)] 75 mg Other ingredients: dicalcium phosphate, vegetable cellulose (capsule), rice flour, vegetable stearate, silica. Contains rice. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, & no artificial sweeteners, flavors, or preservatives.5-LOXIN is a registered trademark of P.L. Thomas & Co., Inc. U.S. patents pending. Dosage & Use Take one capsule daily with or without food, or as recommended by a healthcare practitione