Arigreline is a trademark owned by Barcelona-based Lipotec. It is a proprietary solution of Acetyl Hexapeptide-8. Controlled studies have shown that Argireline improves the appearance of facial areas prone to developing dynamic folds including around the eyes & in the forehead area. Note: Studies have shown that the water content of formulations does impact the utility level of topical Argireline & specifically that higher water content results in better utility. This formulation is water-based & avoids oils esters & silicones. Note: We are deeply grateful to our devoted customers for loving us & our products so much. Our lab has & continues to devote countless hours to share the newest innovations with our broader world. The Ordinary now offers a wide range of products under the Vitamin C Peptide & Direct Acid categories & to help our ever-growing loving family of users build functional & effective routines incorporating these products we have developed an introductory guideline into the br&. Previously we did not have a contraindication listed for the use of direct acids/ Vitamin C with any of our peptides. However we now have a huge arsenal of these products & some of the formulations are more susceptible to hydrolysis with certain types of Vitamin C or acids. Instead of developing a complex guide listing the compatibility of each of our peptides with each acid & Vitamin C we have adapted the following approach to maximize efficacy for the maximum number of people: It is best to not use Peptides in the same routine as the following products: Direct acids LAA (L-Ascorbic Acid) & ELAA (Ethylated Ascorbic Acid). In addition we would recommend avoiding the use of products containing copper peptides in the same routine as strong antioxidants as well as direct acids/LAA/ELAA.