Refresh Opthalmic Eye Drops Solution Refresh Opthalmic Eye Drops Solution provides soothing relief from irritated dry eyes & the symptoms of dry eyes & may also be used as a comfort drop while wearing hard or soft contact lenses. Refresh Opthalmic Eye Drops Solution is supplied in individual single use vials which are portable & convenient. Contact lenses should be removed before applying Refresh Opthalmic Eye Drops Solution & should not be re-inserted for at least 30 minutes afterwards. If you have been advised to use two types of eye medication, there should be an interval of at least 5 minutes between the two medications.