Colgate Sensitive Pro-Relief Multi-Protection Toothpaste Colgate Sensitive Pro-Relief Multi-Protection Toothpaste uses the clinically proven Pro-Argin formula to provide instant & lasting relief from sensitive teeth. While most other sensitive toothpastes primarily numb the pain, Colgate Sensitive Pro-Relief works by plugging the channels that lead to sensitive tooth nerves, to block the pain. With regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. Regular brushing with Colgate Sensitive Pro-Relief Multi-Protection Toothpaste also helps to: Fight cavities. Strengthen enamel. Remove plaque. Remove stains. Promote gum health. Freshen breath.