Canesten Cream Canesten Cream treats fungal skin infections such as ringworm, athlete's foot, fungal nappy rash & fungal sweat rash. It also relieves irritation of the vulva (external thrush) or the end of the penis, which may be associated with thrush. Canesten Cream contains the active ingredient clotrimazole, an antifungal agent which fights the cause of fungal skin infections.