Teva Aciclovir Cold Sore Relief Cream 2g [P] What is Aciclovir cream? Aciclovir cream is indicated for the treatment of labial herpes (cold sores) caused by the Herpes simplex virus. Aciclovir has been shown to decrease both the duration & the pain associated with genital herpes outbreaks. Aciclovir works by preventing the herpes viruses from multiplying. This stops the growth of the virus.