At the hospital bed where Dan lies after a heart attack, Deb contemplates her role in the tragedy. On his way to attempt reconciliation, Dan had found Deb making love to Keith. Meanwhile, Haley & Nathan have gotten married in a ceremony attended only by her parents. Peyton & Brooke begin to recapture their friendship with a day on Brooke's family boat & vow to avoid letting guys come between them again. Whitey learns that he has a brain tumor. & Lucas is living in Charleston with Keith, both having left their problems behind & started new lives. But the news of Dan's hospitalization leads to some soul searching on both of their parts, & when Lucas & Keith arrive back in Tree Hill, life only becomes more tumultuous for everyone involved.