Based on Yoshinaga Fuyumis award-winning comic Ooku: The Inner Chambers, The Lady Shogun & Her Men introduced an alternate reality in which women became the dominant sex after a virus wiped out the majority of the male population. The live-action adaptation project of the Ooku manga series continued two years later with a television drama series (based on chapters two to four), & it now ends with The Castle of Crossed Destinies, the second Ooku feature film. Based on chapters four to six of the manga, The Castle of Crossed Destinies takes place 30 years after the events of the television drama, with its star Sakai Masato starring again as a new character. Playing the all-powerful shogun in this chapter is Kanno Miho, who has to pick one man among 3, 000 suitors vying for her affections & power within the inner chambers.
While most men in the court ruled by shogun Tokugawa Tsunayoshi (Kanno Miho) scheme their way to power by serving as her concubines, Emonnosuke (Sakai Masato) finds his way to power as a dissenting voice against her. When Tsunayoshis only child dies, Emonnosuke promoted to a high position in the inner chamber goes in search for the right man to impregnate the shogun. As Tsunayoshi remains barren over the years, Emonnosuke & the shogun grow closer together.