clinically proven, dermatologically tested, treatment for eczema, dermatitis & insect bites hc 45 hydrocortisone cream is an effective treatment for itching, irritation & inflammation due to: insect bites, mild to moderate eczema, detergent hands, nickel & plant allergies & strong detergent chemicals. hc 45 hydrocortisone cream may also be suitable for insect bites, to provide effective itching relief. it contains a topical corticosteroid, hydrocortisone actetate, which reduces inflammation & relieves itching & irritation for up to twelve hours.