Syndol Caplets are used for the treatment of mild to moderate pain & as an antipyretic. Syndol Caplets are recommended for the symptomatic relief of headache, including muscle contraction or tension headache, migraine, neuralgia, toothache, sore throat, dysmenorrhoea, muscular & rheumatic aches & pains & for postoperative analgesia following surgical or dental procedures. Syndol contains strong painkilling ingredients to lessen the symptoms of the common cold. The Three active ingredients include Codeine A strong painkiller known as an opioid. Codeine works by mimicking actions of painreducing chemicals called endorphins found in the brain & spinal cord blocking the transmission of pain signals. Paracetamol A painkilling medicine though to work by reducing the production of prostaglandins in the brain & spinal cord therefore reducing pain. Caffeine A weak stimulant claimed to enhance the effects of paracetamol & codeine. How do I take Syndol Caplets For oral administration. Adults & children over 12 years 1 or 2 tablets every four to six hours as needed for relief. Total dosage over a 24 hour period should not normally exceed 8 tablets. Do not take for more than three days continuously without medical review. Codeine should be used with caution in the elderly & debilitated patients, as they may be more susceptible to the respiratory depressant effects. Do not exceed the stated dose. Do not take concurrently with any other paracetamol or codeine containing compounds. Keep out of the reach of children. Care is advised in the administration of this preparation to patients with impaired kidney or liver function & in those with hypertension, hypothyroidism, adrenocortical insufficiency, prostatic hypertrophy, shock, obstructive bowel disorders, acute abdominal conditions, recent gastrointestinal surgery, gallstones, myasthenia gravis, a history of cardiac arrhythmias or convulsions & in patients with a history of drug abuse or emotional instability. Codeine may induce faecal impaction, producing incontinence, spurious diarrhoea, abdominal pain & rarely colonic obstruction. Elderly patients may metabolise or eliminate opioid analgesics more slowly than younger adults. The leaflet will state in a prominent position in the before taking section If you need to use this medicine for more than three days at a time, see your doctor, pharmacist or healthcare professional. Taking codeine regularly for a long time can lead to addiction, which might cause you to feel restless & irritable when you stop taking the tablets. Taking a painkiller for headaches too often or for too long can make them worse. If you need to use this medicine for more than three days at a time, see your doctor or pharmacist. Taking codeine regularly for a long time can lead to addiction. Taking a painkiller for headaches too often or for too long can make them worse. You should carefully read all product packaging & labels prior to use When you order this item it is subject to review & approval by one of our pharmacists. Our pharmacists may remove an item from your order if they feel it isnt suitable for you, or in order to comply with UK legislation. Syndol Caplets contain Paracetamol BP 450.0mg, Codeine Phosphate BP 10.0mg, Caffeine BP 30.0mg.