Treatment for Dry Skin Conditions. Effective & pleasant to use, E45 Cream has been clinically proven to treat & soothe dry, itching, flaking, chapped, rough & calloused skin, sunburn & detergent hands. Its non-greasy emollient formulation is quickly absorbed by your skin, leaving it soft, comfortable & relieved. E45 is recommended for more serious dry skin conditions such as eczema, dermatitis, ichthyosis & certain dry cases of psoriasis. E45 Cream can be used everyday by the whole family including babies. Clinically Proven. Perfume Free. Dermatologically Tested.