Vagisil Medicated Creme Vagisil Medicated Creme instantly cools, soothes & relieves external feminine itching due to thrush, perspiration, deodorants or detergents. The fast-acting anaesthetic formula stops itching, cools burning & soothes irritation & forms a protective film over irritated tissue, helping to reduce the chance of further irriation. Vagisil Medicated Creme is lightly scented, non-staining & greaseless.