Drapolene Cream Drapolene Cream is a soothing, antiseptic cream that prevents & treats nappy rash in babies. It can also be used by adults with incontinence to help soothe skin that is sore or likely to become sore because of urine on their skin (urinary dermatitis).in addition, Drapolene Cream can provide relief from minor burns, mild sunburn & sore skin caused by the effects of weather.