Nurofen Sinus Pressure & Headache Relief Tablets Nurofen Sinus Pressure & Headache Relief Tablets provide relief from pain for up to 8 hours & are effective & relieving sinus pressure too. There's nothing stronger for your sinus pain & congestion. Nurofen Sinus Pressure & Headache Relief Tablets contain two active ingredients: Ibuprofen: This targets pain & has anti-inflammatory properties. Pseudoephedrine: This constricts the blood vessels in the nose, helping to open up the nasal passages to make breathing easier.