Nurofen Plus Tablets Nurofen Plus Tablets provide short term treatment of acute moderate pain such as migraine, headaches, neuralgia, period pain, dental pain, back pain & rheumatic & muscular pains. Suitable for adults & children aged 12 years & over, they contain two active ingredients: Codeine: this belongs to a group of medicines called opioid analgesics which act to relieve pain. Ibuprofen: this belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs) which provide relief by changing the body's response to pain, swelling & high temperature. Nurofen Plus Tablets contain codeine & should only be used for pain that is not relieved by other painkillers such as paracetamol or ibuprofen alone. They should be taken for a maximum of 3 days.