Nurofen Cold & Flu Tablets Nurofen Cold & Flu Tablets clear blocked noses & sinuses, relieve aches, pains, headache & high temperature (fever) & ease the discomfort of a sore throat. They contain two active ingredients: Ibuprofen: Belongs to a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs) & is effective against aches & pains (including headache), swelling & can also reduce a fever. Pseudoephedrine Hydrochloride: Acts on blood vessels in the nose to relieve nasal congestion. It belongs to a class of medicines known as vasoconstrictors.