Macleans Iso-active white & Clean Toothpaste 100ml Macleans Confidence with special iso-active technology transforms from a gel into an active foam on brushing, penetrating hard to reach areas in your mouth to whiten teeth. It helps leave behind a clean mouth & a smile that is not just white, but healthy too. Directions: Use as would ordinary toothpaste. Brush twice daily. After use, wipe nozzle clean. This product is not suitable for children under 7 years. As with all toothpastes, if irritation occurs discontinue use.